Natural Substances In The Prevention Of Heart

August 25, 2014

Natural Substances In The Prevention Of Heart

Fruit Flow a Particular Tomato Extract Of Anti Platelet Activity

A new water-soluble derivative of the tomato was presented with the name of Fruitflow and clinical research on this preparation obtained by EFSA (EU Article 13.5 Health Claim) you can use the following claim: Fruitflow helps maintain a normal situation of platelet aggregation , helping to establish and maintain a healthy blood flow . “

Considering the authoritative source of approval , surely we are facing a major innovation in the field of functional natural nutrients and their effects on human health.

By now even ordinary people have become familiar with the values ​​in the blood levels of triglycerides and cholesterol in those of all their clinical forms , and above all , most of them also familiar with their meaning is in a regime of prevention of therapy.

Moreover , numerous clinical studies have scientifically demonstrated that significant levels of Omega -3 (a mixture of EPA and DHA , specific polyunsaturated fatty acids ) are able to decrease the concentrations of triglycerides in the blood dose -dependent , also , can increase the fraction of HDL and improve the LDL / HDL ratio (as well as the report itself Omega6 – Omega3 ) .

The simultaneous intake of B vitamins ( especially B6 and B12 , and folic acid (vitamin B9) helps to lower the values ​​of omocistinemia , converting it to a safer amino acid ( L-methionine ) : remember that high values of Omocistinemia are correlated with an increase of more than significant cardiovascular disease and brain .

Finally, the regular intake of fiber contributes positively to a lowering of blood lipids ( including cholesterol ) .

The problem of the levels of cholesterol and lipids in general are not however the only risk factor to be taken into account for a good prevention of atherosclerosis : as we have already pointed out , this disease is multifactorial and combat one or two risk factors , although important , sometimes it can not represent a safety from the point of view of protection cardio and cerebrovascular , statistically significant.

Another factor pathophysiological has always been considered a priority in the management of atherosclerosis : the platelet hyperactivity caused by certain genetic polymorphisms , or by some pathological states of the organism, but also by the lifestyle of the subject under consideration.

The formation of platelet aggregates with the involvement of clotting factors accordingly is an important pathogenic factor in many cardiovascular disorders : in fact , the sudden occlusion of an artery for the formation of a plug thrombotic ( in the absence of a rupture of the vessel itself ) is the crucial event which induces a deficiency of oxygen , capable of altering the functioning of organs such as the heart and brain.

Platelets play a key role in the maintenance of coagulation : in normal conditions , platelets move freely in the blood stream and do not adhere to one another , but in the case of platelet hyperactivity occur a series of rapid chain reactions , that stimulate the process of blood coagulation and the production of substances that induce platelet activation , a process extremely complex, involving multiple receptors and ligands .

On the basis of these data have been tested numerous classes of antiplatelet drugs such as: the camouflage of the metabolism of arachidonic acid (Aspirin) , the P2Y12 ADP receptor antagonists ( ticlopidine , clopidogrel ) , antagonists glycoprotein IIb / IIIa inhibitor ( abciximab , eptifibatide , tirofiban ) , inhibitors phosphodiesterase ( Dipyridamole , Indobufene ) and receptor antagonists of TP TXA2 ( picotamide ) .

The era of antiplatelet therapy has revolutionized the treatment of cardiovascular disease , the leading cause of death and morbidity in industrialized countries and is still the research in this field continues .

They are , in fact , during the clinical study other molecules that are likely to be issued on the market in the next few years, once demonstrated their efficacy , tolerability and safety .

Insight into the genesis and physiological role of platelets [showhide type”visibility” more_text=”Read insight” less_text=”Hide insight”]

The platelets , figurative element content within the blood vessels , are also called

Thrombocytes : in practice derived from cell fragments that originate from the megakaryocytes in the bone marrow , which in turn come to life from a totipotent stem cell .

This cell undergoes a cure for endomitosi ( nuclear division , but not cytoplasmic ) giving rise to the megakaryoblast and subsequently to the megakaryocyte from which are formed from 2,000 to 8,000 platelets in 3-12 hours.

Most of megakaryocytes in the bone marrow and remains free platelets in the circulating blood ; some, however, can enter the blood and be transported in other organs, particularly in the lung , where they remain and produce thrombocytes .

Platelets appear as small spherical particles , oval or elongated , bordered by membrane , anucleated and with a diameter of 2-4 mM : the larger ones are younger and then metabolically and functionally active , as they age , they undergo a process of fragmentation and therefore are smaller.

They are present in the blood in a variable number from 150,000 to 350,000 per microliter and have an average life of about 10 days, and if they are not consumed in the process of coagulation , undergo destruction by macrophages of the liver and spleen .

Platelets contain two specific types of granules , those α that express on their membrane adhesion molecule P- selectin and contain fibrinogen , fibronectin , factor V and vWF , platelet factor 4, the platelet-derived growth factor (PDGF ) and the transforming growth factor – β (TGF- β ) , the other granules are dense bodies or granules which contain nucleotides δ adenine (ADP and ATP) , calcium ions , histamine, serotonin and epinephrine .

Platelets have several functions :

  • Hemostasis : they have an ability to adhere to the margins of the vessels and aggregate forming the so-called white platelet thrombus ; also facilitates fibrin formation freeing important coagulation factors and involved in clot retraction ;
  • Inflammation: In addition to its role in hemostasis , platelets release also biologically active substances that have a role in the response inflammatory ; vasoactive amines , such as serotonin and histamine, can contribute to start the inflammatory response ; also neutrophils and monocytes produce substances that activate platelets , promoting aggregation and inducing the release of new vasoactive substances .
  • Phagocytosis : the platelets engulf bacteria and small particles and bind collaborating in the detoxification of plasma endotoxin , the material extraneous small is phagocytosed through the system of channels existing on the membrane.

The most important function of platelets in hemostasis , that is the mechanism that minimizes or prevents the loss of blood following an injury to endothelial cells , it is which comprises several stages :

Vascular phase : immediately after the injury you have a local vasoconstriction due to a factor that is endothelin and the reduction of blood flow ;

Platelet phase : with the formation of ” white thrombus ” ; this phase within a few minutes from the lesion and , together with the vascular phase , constitutes the process known as hemostasis , which is typically enough to repair the capillary lesions ;

Coagulation phase : in the case of deeper lesions the primary haemostasis is not sufficient to repair the damage, it has thus the transformation of prothrombin to thrombin , which converts fibrinogen to fibrin , forming the clot or “thrombus red” .

Fibrinolytic phase : finally, there is the retraction of the clot , due to a protein contractile , the trombostenina , after the bleeding has stopped , the clot is gradually dissolved by the degradation of the fibrin in soluble fragments by the enzyme plasmin.