Polyphenols and inflammation – Insight

Polyphenols and inflammation – Insight

More intriguing, today we are able to understand the origins of inflammation and to quantify its expression better and better. With the help of some inflammation test, already on the market, it is possible to measure and self-measure the values of inflammatory cytokines like BAFF (B-cell activating factor) and PAF (platelet-activating factor). This can provide anyone with a wider and more complete vision of his or her personal inflammatory status. As a consequence of such a better knowledge, the therapeutic opportunities become more and more precise, not only in terms of medicines, but also in terms of various natural nutraceuticals shown today to possess a specific action on peculiar inflammatory cytokines. The polyphenols group includes the flavonoids (including flavones and anthocyanins, typically found in maqui fruit and blueberries), the phenolic acids (such as salicylic acid and gallic acid), the stilbenes (resveratrol is part of this group) and the lignans (present in cabbage and broccoli). To come back to our beloved natural substances such as grapes, propolis, purple corn (characterized by important actions leading to fat break-up), and wood berries (maqui or blueberries are the best examples), every day we keep discovering novel polyphenols, able to stop the leucocyte-mediated release of inflammatory mediators or to reduce the arthritis manifestations in experimental models (Mossalayi MD et al, Phytomedicine. 2013 Sep 19. pii: S0944-7113(13)00318-8. doi: 10.1016/j.phymed.2013.08.015. [Epub ahead of print]). In our clinical practice (SMA), we are fully aware that a regular use of certain natural products, as the ones indicated above, supports the treatment of various arthritis forms and of other chronic conditions so much, that for many years we have kept recommending their employment in specific therapeutic courses. Nevertheless, the benefits of polyphenols are due to a more general mechanism, whose specific pathway of action is available today to be fully appreciated. The American researcher Chu recently published an article on the Inflammation and Allergy Drug Targets journal, mechanistically describing all these powerful molecules (Chu AJ, Inflamm Allergy Drug Targets. 2014 Feb;13(1):34-64), and demonstrating their regulatory action on the Toll-like receptors (TLRs), which means, in other words, that these substances act at the level of the innate immunity. The consequence of this action is the inactivation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), a central molecule for every reaction triggering insulin resistance, and for the reduced production of many pro-inflammatory mediators. Therefore, polyphenols can be active components in the modulation and in the resolution of inflammatory processes. Such benefits should be exploited in the future to support both therapies and prevention of many common disorders. Attilio Francesco Speciani MD – GEK srl Clinical Immunologist and Allergy...

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Natural Substances In The Prevention Of Heart

Natural Substances In The Prevention Of Heart

Fruit Flow a Particular Tomato Extract Of Anti Platelet Activity A new water-soluble derivative of the tomato was presented with the name of Fruitflow and clinical research on this preparation obtained by EFSA (EU Article 13.5 Health Claim) you can use the following claim: Fruitflow helps maintain a normal situation of platelet aggregation , helping to establish and maintain a healthy blood flow . “ Considering the authoritative source of approval , surely we are facing a major innovation in the field of functional natural nutrients and their effects on human health. By now even ordinary people have become familiar with the values ​​in the blood levels of triglycerides and cholesterol in those of all their clinical forms , and above all , most of them also familiar with their meaning is in a regime of prevention of therapy. Moreover , numerous clinical studies have scientifically demonstrated that significant levels of Omega -3 (a mixture of EPA and DHA , specific polyunsaturated fatty acids ) are able to decrease the concentrations of triglycerides in the blood dose -dependent , also , can increase the fraction of HDL and improve the LDL / HDL ratio (as well as the report itself Omega6 – Omega3 ) . The simultaneous intake of B vitamins ( especially B6 and B12 , and folic acid (vitamin B9) helps to lower the values ​​of omocistinemia , converting it to a safer amino acid ( L-methionine ) : remember that high values of Omocistinemia are correlated with an increase of more than significant cardiovascular disease and brain . Finally, the regular intake of fiber contributes positively to a lowering of blood lipids ( including cholesterol ) . The problem of the levels of cholesterol and lipids in general are not however the only risk factor to be taken into account for a good prevention of atherosclerosis : as we have already pointed out , this disease is multifactorial and combat one or two risk factors , although important , sometimes it can not represent a safety from the point of view of protection cardio and cerebrovascular , statistically significant. Another factor pathophysiological has always been considered a priority in the management of atherosclerosis : the platelet hyperactivity caused by certain genetic polymorphisms , or by some pathological states of the organism, but also by the lifestyle of the subject under consideration. The formation of platelet aggregates with the involvement of clotting factors accordingly is an important pathogenic factor in many cardiovascular disorders : in fact , the sudden occlusion of an artery for the formation of a plug thrombotic ( in the absence of a rupture of the vessel itself ) is the crucial event which...

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The juice of the pomegranate

The juice of the pomegranate

Different studies carried out in various parts of the world confirm that pomegranate juice or rather some substances obtained with a particular extraction , represent one of the richest sources of natural antioxidants . (1-3 ) Recent research , not only confirm what has been said before, but allow to hypothesize as continued use of such extracts can delay the atherosclerotic process and / or even , in some cases , ” reverse it .” These amazing results indicate that the pomegranate is able to ensure a cardiovascular protection unprecedented , restoring a normal state endothelial , but also to lower the blood pressure and prevent the oxidation of low density lipoproteins (LDL ) , the first mover of the process atherosclerotic borne by the arterial endothelium . The good news for consumers that are available today are titrated extracts accessible and highly purified .The pomegranate increases the endogenous production of nitric oxide , improving endothelial function The pomegranate, therefore, is able to perform a protective action on the entire cardiovascular system, contributing among other things to increase the production of nitric oxide (as does arginine ), optimizing the functioning of the endothelial cells of the arterial vessels which are thus “normalized ” with regard to their arteriolar tone base. Nitric oxide acts on vascular smooth muscles , dropping : the blood , consequently, more orderly flow with flow through the arteries and veins. Nitric oxide reducing the arteriolar tone will decrease wall stress , a key factor in triggering and / or support the atherosclerotic process . (4) Specific research on this subject demonstrate how the oxidized low-density lipoprotein (LDL ) can have a negative impact on the synthesis of nitric oxide , decreasing the active catalytic enzyme nitric oxide synthase. The present research on pomegranate ( and its extracts ) showed a strong stimulus to the activity of nitric oxide synthase (5): and again, the antioxidant properties of pomegranate , preserving nitric oxide from oxidative destruction , increasing its bioavailability tissue . (6,7). An Italian study examined the role of pomegranate juice on the activity of nitric oxide synthase in samples section of the artery of rabbit which had already developed some degree of atherosclerosis. (8 ) . In these segments , the blood flow is hindered in the regular path due to the presence of plaques sub -endothelial cells , and the result is an increase in wall tension ( > wall stress ) with a consequent action of proliferation of atherosclerotic phenomenon already in place (hypertrophy and hyperplasia of myocytes ) . This increase in wall stress reduces the expression (and hence the activity) of nitric oxide synthetase , favoring the development and / or...

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A patented Klamath Algae extract for anti aging

A patented Klamath Algae extract  for anti aging

Though hormone replacement therapy (HRT) represents a beneficial treatment during peri end post menopause, in some situations alternative options and solutions need to be considered. At present, HRT is the putative first choice of the gynecologist to overcome menopausal symptoms when no contraindications are present, but specific and effective natural compounds can be used as well. Such natural compounds are of great interest since most of them do not have estrogen-like activity and for this reason are a very good choice during the menopausal transition for those women that refuse hormonal replacement therapy either for personal choice or for objective reasons, such as a personal or familiar history of breast cancer, venous thrombo-embolism, severe cardio-vascular diseases, liver diseases or other pathologies. According to our experience among the possible alternative choices to HRT the specific Klamath algae extract Klamin®stands out, which concentrates neuroactive molecules present in the unique wild blue-green algae, Aphanizomenon flos-aquae (AFA), which naturally grows in Upper Klamath Lake (Oregon, USA). The AFA extract is an completely natural product, with no side effects and that has shone to be with very effective on climateric complaints and symptoms (1). The AFA extract concentrates phenylethylamine (PEA), a molecule  naturally present in the algae, endowed with a significant dopaminergic and serotoninergic activity. The extract  concentrates PEA to the point that it can act as a powerful neuromodulator and mood enhancer. However, since PEA is quickly destroyed in the body from the MAO-B enzymes, the extract concentrates also other molecules, like the AFA-phycocyanins and algal mycosporines (porfira and shinorine), that have shown to be the most powerful  selective MAO-B physiological inhibitors among all natural substances. It is this synergy pf PEA and MAO-B inhibitors that makes the extract effective as a general neuromodulator (1-3). In addition, the extract still retains some nutritional components of Klamath algae, such as B vitamins, chlorophyll and beta-carotene, whose antioxidant action is compounded with that of the AFA-phycocyanins, that among other things have proved to possess a powerful neuroprotective activity (4). We recently reported our experience on a group of menopausal women treated with the Klamathextract for 2 months (5), evaluating the changes in the levels of oxidative stress and of several anti-oxidant factors. Our report demonstrated that the administration of 1.6 g of Klamath extract every day (2 tabs of 800 mg each: 1 at 10 am  and 1 at 4 pm) significantly reduced (-38%) the blood levels of malondialdehyde (MDA), a very significant marker  of oxidative stress as it specifically indicates the degree of lipoperoxidation (oxidation of the lipid components of the cells); while  increasing the concentration of liposoluble vitamins (α-, δ- and γtocopherol, retinol, lutein, lycopene, α- and β-carotene) as non-enzymatic antioxidants (5-8). No...

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PQQ : pyrroloquinoline quinone

PQQ : pyrroloquinoline quinone

A “new” enzyme co-factor related to family of Ubichinolo   The PQQ is easily found in natural substances : it was also found in stellar dust , confirming the hypothesis of a role in the evolution of life on earth ! All known plants contain PQQ , but neither the human nor the bacteria are able to synthesize it , and this has convinced the experts to classify the PQQ as an essential micro- nutrient . More about the discovery of PQQ Japanese scientists have discovered a new vitamin that plays an important role in the fertility of mice and that could have a function quite similar in humans . The research team , led by Takafumi Kato Institute of Physical and Chemical Research ( RIKEN ) in Tokyo, confirmed that the ( PQQ ), a substance discovered in 1979 , can be labeled as a vitamin. Mice deprived of PQQ have reduced fertility and have a bit more rough ; vitamins that have an effect on mice , said Kato , usually act in the same way in humans. “There are many factors that could have something to do with this decline in fertility , – explained the researcher – and we will need many more studies to find out exactly what happens to these mice and what would be the effects on humans .” PQQ is the first new vitamin discovered since 1948 ; vitamins , organic substances needed in small quantities for health and growth, and must pyrroloquinoline quinone obtained from food can not be produced by the body.There are 13 other types of vitamin known : the PQQ should be part of the group of B vitamins The best source of PQQ that is known so far is the ” natto ” , a Japanese dish made ​​from fermented soybeans . Other foods rich in this substance include parsley, green pepper , green tea , kiwi and papaya . Currently it is not included in the multi- vitamin tablets available on the market. PQQ has the potential to stimulate the biogenesis of mitochondria and research in this direction further confirm a role of strategic importance in the production of cellular energy , so much so that he was given a role of powerful growth factor for plants, bacteria but also to higher organisms . Recent clinical studies show that farmed animals by depriving them of the cofactor show difficulties in the normal growth , a simultaneous impairment of the immune system , reproductive dysfunction , and , of course, a decreased number of cellular mitochondria . In addition, shortage or absence of PQQ decreases the amount of newborns , their survival statistics, and their general...

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