The effects of Probiotics on autism

The effects of Probiotics on autism

A report was published this month in the Journal of Developmental & Behavioral Pediatrics which explain as parents of young children with neurodevelopment or autism spectrum disorders frequently try to help their children by adding alternative medical therapies to the conventional treatments. They found that 39.3% of autism-affected families and 29.6% of families with a developmentally delayed child used complementary or alternative medicine. Most commonly, parents gave children dietary supplements. These were used by 24.7% of the families with a child on the autism spectrum and 18.4% of families with a developmentally delayed child, the researchers note. The study included 578 children aged from 2 to 5 years; 453 of them met diagnostic criteria for an autism spectrum disorder, and 125 had a developmental disability. Alternative medical therapy usage was more likely in families in which at least 1 parent had a bachelor’s degree than in families without this level of education. In addition, parents of children on the autism spectrum were far more likely to use a gluten-free, casein-free diet than were parents of children with developmental delays. A study conducted by investigators at the California Institute of Technology in Pasadena shows that treatment with the human gut microbe Bacteroides fragilis alleviates autism spectrum disorder (ASD) -like behaviors and eases comorbid gastrointestinal (GI) symptoms in a mouse model of autism. Neurodevelopmental disorders, including ASD, are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites. Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior. Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders. Probiotics may have therapeutic potential in autism spectrum disorder (ASD), new research...

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Ledum against mosquitos

Ledum against mosquitos

The properties of this plant, also called marsh rosemary, once it has been diluted highlights its powerful action in cases of trauma, rheumatic diseases and blood transfer processes (bruising, bloody). Surely this is one of the main reasons why this homeopathic remedy has incredible curative and preventive action after mosquito bites: in fact the effect is recognized on both the trauma of insect bites, inflammation is done by the poison and is the bleeding of mosquitoes in the area of ​​the bite. This curious application is perhaps the most popular part of this remedy, but Ledum has a vast field of action in rheumatic diseases, is useful in inflammation and lesions. The rheumatic patients who may benefit from this remedy are those in which the attack is usually related to acute inflammation that usually starts in the feet or legs and gradually spreads upward (hip, shoulder …). The seizures begin at night with the warmth of the bed, the pains are irregular or cross, pains change of articulation (knee now right, now left shoulder …). It is an excellent remedy for all illnesses of the knee, whoever is the cause, and combined with Argentum metallicum has a regenerative effect in this articular cartilage. It is also useful in case of pain in the knuckles, fingers and soles of the feet, ankles, knees. It is sometimes present in people prone to sprains and strains. These discomforts worsen with the heat of the bed and always improve with a cold water bath. Other situations in which you Ledum is useful are itching of the feet and ankles, which worsen with scratches and with the warmth of the bed, in wounds and ulcers resulting from any injury with a sharp instrument, especially when it is accompanied by bruises or bruises and the wound looks bloody, with bright red blood. Special mention deserves the typical trauma “black eye”: here the cause is always some type of trauma, with extravasation of blood, and the patient needs to alleviate with cold applications. In all these cases the patient Ledum needs of applications or cold baths. Is it useful to prevent mosquito bites? Ledum is extremely useful to prevent itching, inflammation and bleeding produced from mosquito bites. In this case the granules of 9 CH Ledum palustre are usually three or four times a day five granules. While we are taking this homeopathic remedy some patients will “immunize” against the normally produced in the body by the bite of mosquitoes annoying reaction...

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The extraordinary properties of Feijoa

Feijoa is the Portuguese name for Acca sellowiana. The name by which it is generally known comes from its discoverer naturalist João da Silva Feijó. It is an evergreen native of the sub-tropical zone of South America. It belongs to the Myrtaceae family which was later spread to California, Florida and Mediterranean Europe. In Italy it is found in the Ligurian Riviera, in the South and the Islands. The fruits are very fragrant and the pulp has a taste that is something between pineapple and strawberry. Acca sellowiana is rich in iodine, the fresh produce has roughly 3%. Additionally it does not contain cholesterol, on the contrary, it lowers the level and keeps the cardiovascular system healthy as it contains omega-3 and omega-6 polyunsaturated fatty acids. Both the fruit as well as the leaves, but especially the seeds, have antibacterial properties especially against Helicobacter pylori, involved in gastritis, ulcers and stomach diseases. The fleshy and fragrant fruits also have antioxidant properties and are an excellent source of fiber, essential for health and proper functioning of the intestine. Other important contents are vitamin C and K, with antioxidant properties, as well as folic acid, which ensures the proper formation of the nervous system of the fetus. Arginine is also present, an amino acid involved in growth processes, which is good for young children and pregnant women. Feijoa is used in the treatment of goitre. Even the flowers of this plant are eaten and are truly delicious. Excellent both fresh and for the preparation of...

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The tonic-adaptogen activity of Withania somnifera

The Withania somnifera, known as ashwagandha in ayurvedic medical tradition, or with the popular name of “Indian ginseng”, is a plant belonging to the family Solanaceae. It is a shrub, with woody base, which can reach a height of about 2 meters. Its flowers are greenish-yellow and the fruit color varies from yellow-orange to red depending on the stage of maturation. The plant is covered with tiny hairs that give reflections silver-gray. They belong to the genus Withania many as 23 different species, but of these, only the Withania somnifera is known to have medicinal properties. It is cultivated, but grows spontaneously in India, Pakistan, Sri Lanka, and also in parts of ‘North Africa and the Mediterranean, for example in Italy is located mainly in Sicily and Sardinia. The term “ashwagandha” comes from the Sanskrit word “Ashva”, meaning horse, and “gandha”, that smell; in fact the root of Withania has a strong smell that vaguely resembles that of the horse. It is known and used since ancient Ayurvedic medicine, as an adaptogen, aphrodisiac, liver tonic, astringent, and for its anti-inflammatory and immunomodulatory properties. Withania is the fact mentioned in the canonical texts Ayurvedic dating back to the period between the first and the eighth century BC. The main constituents of the root of Withania are alkaloids and steroidal lactones or withanolides. The Whitania has adaptogenic properties, anti-stress, anti-inflammatory, immunomodulatory, anticancer, antioxidant and hematopoietic. It also attributed the ability to exert beneficial effects, through mechanisms of action have not yet been spelled out, on the endocrine system and on the cardiovascular and respiratory systems, as well as on the CNS. The pharmacological effects of Withania however, seem to depend primarily from the organism of the steroidal lactones, or witanolid in it. At the base of the adaptogenic properties it seems to be a fact inhibit the up-regulation of dopamine receptors at the striatum induced by stress. The immunomodulatory effects of the plant seems to be related to the property to induce the synthesis of nitric oxide by macrophages, thus promoting the oxidative burst by the latter. Many scientific studies seem to confirm the anti-inflammatory, anti-stress, antioxidant, immunomodulatory, hematopoietic and anti aging properties. It was also highlighted sedative-hypnotic activity that appears to be beneficial in the issues of sleep and the stress related anxiety. The Withania is still useful even in healthy individuals, stressed from the commitments of everyday life, which can give an invigorating effect and help concentration, skills and activities of the attention. For example, in a prospective clinical study, double-blind, placebo-controlled, we have evaluated the effects, on a cognitive and psychomotor, an extract of Withania. The study involved 20 healthy volunteers, in which cognitive performance was assessed before...

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Rosemary against brain aging

Rosemary against brain aging

Rosemary (Rosmarinus officinalis) of the Labiatae family, has an ancient tradition in phytomedicine. Young shoots , leaves and flowers are used. They contains both essential oils ( eucalyptol , camphor, verbenone, cineole and bornyl acetate ), both in the phytocomaplex, carnosic acid , the most active component of rosemary. This plant support the recovery of mental energy, concentration, safety and motivation. Recent research has revealed that some fractions present in rosemary act as stimulants and activators of certain brain centers such as the locus coeruleus (with the consequent release of norepinephrine) in the hippocampus and the amygdala (with the release of neurohormones that influence the ‘cortical activation). Used since the Middle Ages to treat disorders of the nervous system and to ward off sickness. It has neuroprotective effects without producing serious side effects characteristic of many agents used to treat neurodegenerative diseases. This type of compound may well be safe and clinically tolerated because it is present in a naturally occurring herb that is known to get into the brain and has been consumed by people for over a thousand years. This agent activates a new signalling cascade that protects brain cells from free radical damage observed in stroke and other degenerative diseases such as Parkinson’s disease or Alzheimer’s . In animals it has been noticed that the a carnosic acid is activated by free radicals, but otherwise remains harmless , which could lead to the development of new drugs. The rosemary could be the ideal solution in the clinical use of potentially neuroprotective treatments. Two studies issue of Nature Reviews Neuroscience show that carnosic acid activates a novel signalling pathway that protects brain cells from free radical damage, seen in stroke and other neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases. In animal experiments, the investigators found carnosic acid is activated by the free radical damage but otherwise remains innocuous, a finding that may signal a major breakthrough in the development of drugs to treat neurodegenerative disease. According to the investigators, animal experiments showed carnosic acid activates the Keap1/Nrf2 transcriptional pathway by binding to specific Keap1 cysteine residues, protecting neurons from oxidative stress and excitotoxicity. The study also suggests that carnosic acid may protect the brain against middle cerebral artery ischemia/reperfusion. This new type of agent, known as a pathological-activated therapeutic (PAT) drug, works though a mechanism known as redox chemistry, in which electrons are transferred from 1 molecule to another to activate the body’s own defense system. However, the identification of carnosic acid and its potential beneficial effect in the brain should lead to the development of better and more effective neuroprotective agents. Some researchers have filed a US patent application for a whole series of novel...

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