Energy and information control matter. The exchange of information between cells occurs through structures that directly link a cell to another, the conversations deal with processes and activities of all types, from the timing of the heartbeat to hearing. Joints are continuously disassembled and reconstructed and are made up of more than 100,000 protein molecules. These restructuring processes, closely monitored, allow the cells to respond quickly to injury or stress. Various gene mutations that codify joint proteins cause diseases, ranging from skin disorders to heart disease, epilepsy and deafness. Studies are focused on understanding how these defects affect the assembly and activity of the joints, so as to find new therapeutic strategies.