They are used in all manifestations that are characterized by a null or greatly reduced response to stimuli and impairment of defense mechanisms. They facilitate general recovery and reduce the incidence of infections.

Characterized by lack of vitality and adaptability of the organism (convalescence, results of recent or remote trauma, following surgery, repeated inflammation and infection and with slow resolution, compromised general state of being, depression).

They may be transient or mild as in convalescence or persistent in the aforementioned situations even with serious injuries.

Progressive loss of memory with general attitude of renunciation as well as a tendency to isolation and depression.

General fatigue does not improve with rest. Tendency to depression